Genome Center

The Genome Center was established in accordance with the Order of the Ministry of Health of the Republic of Kazakhstan No. 134 of 14.03.2011. The opening of the laboratory took place on October 30, 2012.

The head of the Genome Center: Zulfiya Sabirkizi Kachieva

email: [email protected], [email protected]

On December 15, 2021, under the leadership of the head, Zulfiya S. Kachieva, there was a completely re-opening of the modernized and expanded Laboratory, with a developed infrastructure and full equipment.

The material base of the Genome Center

At present, the laboratory area is 536 square meters, with separate clean rooms equipped with their own supply and exhaust ventilation system.

The laboratory has the only robotized system in the territory of the Republic of Kazakhstan for registering, tracking, and storing biological samples, the STC Compact ULT (by LiCONiC AG, Liechtenstein).

At the Genome Center, active research is conducted in the field of molecular genetics within various scientific projects. For these purposes, the laboratory is equipped with state-of-the-art high-level equipment, including instruments for Next Generation Sequencing (MiSeq System, Illumina, USA), genome-wide association studies (Affymetrix GeneTitan, Thermo Fisher Scientific, USA), as well as PCR technologies (QuantStudio 5 Real-Time PCR System, QuantStudio 12K Flex Real-Time PCR System, and QuantStudio 12K Flex Accufill System, Thermo Fisher Scientific, USA).

These cutting-edge tools are an integral part of the laboratory infrastructure, enabling precise and in-depth genetic research on biological samples. Our team actively employs advanced methodologies and technologies to achieve outstanding results in the field of molecular genetics, contributing to the progress of scientific knowledge and the advancement of medicine.

Research work of the Genome Center

The Genome Center successfully concluded a genetic research project as part of the Programmatic Funding on Personalized Medicine initiative. During this endeavor, a biological sample bank was established, encompassing 20,000 samples from all regions of Kazakhstan, as well as 7,000 samples related to 10 different diseases. The laboratory conducted genomic analysis of these samples, aiming to identify genetic associations, predisposition markers, and ethnic characteristics. The resulting findings represent a significant contribution to the advancement of genetic research and the medical database within the region.

The laboratory continues its active participation in cutting-edge projects, contributing to the development of the scientific community in Kazakhstan.

The Genome Center staff

The laboratory staff is highly qualified, with all researchers holding specialized education in biotechnology and biology. They possess comprehensive skills in operating all the laboratory equipment and have a broad range of expertise in molecular biology, biochemistry, chemistry, and genetics. Moreover, some team members are capable of assuming the role of trainers, conducting training sessions on molecular genetic methods.

Staff of the Genome Center

Full name Job title
Kachieva Zulfiya Sabirkyzy Head of laboratory
2. Smagul Aibek Orazakuly Senior researcher
3. Tolegenkyzy Aiganym Researcher
4. Bismildina Gauhar Symbatkyzy Researcher
5. Tileules Zhanerke Berikkyzy Researcher
6. Kovaleva Kristina Dmitrievna Researcher
7. Turarova Dinara Bakytovna Junior researcher
8. Rakhitova Nurgul Aripbaevna Senior assistant
9. Karazhanova Aigerim Bakhytovna Laboratory assistant

Capabilities of the modernized genomic laboratory:

Collection and storage of large volumes of biological material using an automated sample storage system.

The conduct of various types of PCR (Polymerase Chain Reaction).

The execution of sequencing procedures.

The implementation of high-throughput next-generation sequencing.

Conducting genome-wide association studies.

Performing bioinformatics and statistical analyses of acquired data to derive final interpretable results for research purposes.

At present, the laboratory area covers 536 square meters, including separate clean rooms equipped with their own supply and exhaust ventilation system.

The robotic system for registering, tracking, and storing biological samples is the STC Compact ULT (by LiCONiC AG, Liechtenstein).

In 2021, the laboratory acquired the microarray system Affymetrix GeneTitan™ (Thermo Fisher Scientific, USA).

The MiSeq Sequencing System by Illumina, USA, is a powerful and efficient high-throughput system for Next-Generation Sequencing.

The Real-time PCR Amplifier QuantStudio 12K Flex is a high-performance, multifunctional instrument used for nucleic acid amplification in real-time.

The QuantStudio™ 12K Flex Accufill System is an innovative system developed by Thermo Fisher Scientific, designed for automated and precise plate filling in sample preparation for laboratory research.